时间：8月24日星期二16:00-17:30    

Time：4:00-5:30 PM，Tues., August 24th，2021

地点：西湖大学云栖校区3号楼312会议室

Venue: Room 312, 3F, Building 3, Yunqi Campus

主持人：西湖大学生命科学学院讲席教授 裴端卿

Host：Dr. Duanqing Pei, Chair Professor, School of Life Sciences

主讲嘉宾/Speaker:

Dr. Maria Pia Cosma

Principle Investigator, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences

Dr.

Maria Pia Cosma, PhD in Cellular and Molecular Genetics, 2000, then Marie Curie Post-doc at IMP, Vienna. Junior PI at TIGEM, Naples and EMBO Young Investigator in 2003. In 2010 Senior PI and ICREA Research Professor at CRG, Barcelona, Spain. In 2018 faculty at GIBH-GDL, Guangzhou, China. Awarded several prizes including: Marie Curie Excellence Award, 2005; honour of Order of Merit of the Italian Republic, 2007; Barcelona City Prize in 2015; EIC National Champion, 2021. She is ERC stGrant awardee, 2009; HFSP Grant awardee, 2010; coordinator of the FET-Open project in 2016 and 2020. She is EMBO Member since 2010. Cosma’s group has the main objective to investigate the controlling mechanisms of stem cell maintenance, the reprogramming of somatic cells, and tissue regeneration. The laboratory uses different approaches ranging from the nanoscale imaging of the chromatin to complex systems.

讲座摘要/Abstract:

Dissecting the functional modifications of the chromatin during somatic cell reprogramming to pluripotency and during differentiation is a key area of investigation. By using quantitative super-resolution nanoscopy, we identified a novel chromatin fiber assembly and its relation with naïve pluripotency. Nucleosomes arrange in groups of various sizes along the chromatin fiber, named ‘nucleosome clutches’ and they are interspersed with nucleosome-free regions. We recently visualized and studied the structure of cohesin-mediated loops in human cells and discovered how transcriptional activity controls loop formation and 3D-genome organization. I will discuss our recent advances in this research area.